All About AMPK Activators
To ensure that the body is functioning properly, AMPK is crucial as it is regulating the maintenance of cellular energy homeostasis. When it comes to AMPK in mammals, this works by regulating energy balance both on cellular level through sensing ATP/AMP and ATP/ADP ratio levels and at the same time, whole body by means of responding to the hormones and the brain.
ATP is actually the most significant energy molecule present in the body. In essence, this is the starting point of cellular function. ATP breaks down into ADP that has less potential for energy since the cells are using energy. ADP is broken down to AMP containing the least energy potential among all 3. In reality, this is where AMPK is used; it senses the ratios of ATP/ADP/AMP and it tells the body if it requires more ADP so by that, it will be able to maintain optimal functions.
There are different mechanisms in which AMPK acts on. This makes sense since AMPK is the master regulator of all functioning cells. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. Still, there are many different benefits of having increased AMPK and these are:
Anti aging – as we begin to age, AMPK activation begins to decline. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. AMPK is important because it helps in having adequate level of new mitochondria and promotes cellular renewal as well.
Anti inflammation – inflammation decreases the level of AMPK activation in the body but what’s interesting is that, AMPK is used as well to decrease inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
There are lots of herbal products/constituents and nutritional products too that are proven to be effective as AMPK activator and few of these are:
Number 1. AICAR – this is the analog of AMP which is needed in cellular use and storage similar to ATP. Because it is AMP’s analog, AICAR has the capability of stimulating AMPK’s activity directly which can actually boost muscle performance.
Number 2. ALA – ALA or in this case, Alpha Lipoic Acid is not just an effective antioxidant but also, a powerful AMPK activator. It’s been shown to boost the sensitivity of insulin in the body and also, carries anti obesity effects.
Number 3. Green tea extract – actually, this was discovered to assist in the activation of AMPK by activating upstream kinase.
Number 4. Berberine – because of its AMPK activation, berberine was discovered to carry the same anti diabetic effects as metformin.